Scientists Discover How Diabetic Patients Lose Their Sight

By Donna Parker • Apr 1st, 2010 • Category: Blood Sugar, Health Articles, Health News, Thursday Edition

Vision can be affected by diabetes While natural remedies may help patients with diabetes control their symptoms, they are still more susceptible to certain diabetic problems such as blindness. Until recently, physicians did not know how high blood sugar levels damage blood vessels in the eye.

According to researchers from Michigan State University, when blood sugar levels rise a protein known as siah-1 is produced, which shuttles the protein glyceraldehyde-3-phosphate dehydrogenase (GAPDH) into the nucleus of the Müller cells. Müller cells have contact with the blood vessels of the eye. The GAPDH protein kills the Müller cells, which causes loss of sight, or diabetic retinopathy.

Previous studies knew that GAPDH had something to do with the destruction of the Müller cells; however, no one knew how the cells were transported to the area. The researchers believe this could lead to new treatments.

"This is very exciting," said researcher Susanne Mohr. "We know that we can’t regulate production of GAPDH because it’s necessary for producing energy throughout the body. But since siah-1 is produced only when glucose levels are high, regulating it doesn’t cause any problems. If we can [ find] out how to stop siah-1 production, it may lead to new treatments for diabetic retinopathy." ADNFCR-1960-ID-19601483-ADNFCR

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